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SuperEnro™ (Bitterness-free Enrofloxacin 10% & 20% Premix Specifically for Swine)

SuperEnro™

(Bitterness-free Enrofloxacin 10% & 20% Premix Specifically for Swine)

The latest cutting edge technology of bitterness overcoming is adopted in producing SuperEnro™, which turns out to be, so far, the smartest solution to the unsettled but common problem of feed refusal in swine if taste of enrofloxacin is present. Bitterness is the main disadvantage of the ordinary enrofloxacin and the effect of the swine disease control is consistently decreased to a great extent because of the feed refusal.

 

Composition

1 gram of SuperEnro™ contains:

Enrofloxacin (active ingredient) …………………………………… 100 mg (10%) /200 mg (20%)

Excipients/carrier: …………………………………………………….Corncob meal and stearic acid

 

Typical Physical Properties

Physical appearance……………………………………….. Off-white or yellowish microgranules

 

Indications

The treatment of primary or secondary infections produced by Gram-positive, Gram-negative germs and mycoplasmas for swine:  Haemophilus parasuis, Infectious pleuropneumonia, swine enzootic pneumonia, Pasteurellosis, Salmonellosis, Streptococcus suis, E.coli infection, various respiratory infections, anaerobic organism, mixed & secondary infections, and others.

Pharmaco-Therapeutical Action

Enrofloxacin is a third-generation fluoroquinolone antimicrobial. It is a chemo-therapeutic substance with a wide range of powerful anti-microbial actions, even over the germs resistant to antimicrobial. It is a fluorite 4-quinolona derivative, joining the last generation of synthetic quinolones and having the lowest toxicity of the whole group of quinolones.

 

Enrofloxacin is a bactericidal agent. The bactericidal activity of enrofloxacin is concentration-dependent, with susceptible bacteria cell death occurring within 20–30 minutes of exposure. It has demonstrated a significant post-antibiotic effect for both Gram-negative and Gram-positive bacteria and is active in both stationary and growth phases of bacterial replication. Thus enrofloxacin has antibacterial activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Its mechanism of action is not thoroughly understood, but it is believed to act by inhibiting bacterial DNA gyrase (a type-II topoisomerase), thereby preventing DNA supercoiling and DNA synthesis.

Dosage, Administration Way and Mode

Calculated on the basis of 10% premix,

 

1) for the prevention of diseases, it is, , administered in a dose of 0.5 kg product/ 1000 kg feed (2,5 – 5 mg s.a./kg.g.c./ day) for 3-5 days;

2)therapeutically, it is administered in a dose of 1 kg product/ 1000 kg feed, (5 mg s.a./kg g.c/ day), for 5 days.

Cautions

Not recommended for use in pregnant or lactating sows.

 

 Waiting/ Withdrawal Time

7 days before slaughter.

Storage Conditions

To be stored in the original packing, well closed, in dry and well-ventilated facilities; to be protected from direct sunlight at temperature between 15° and 25°C. 

Packaging

To be packed in 25 kg PE-lined multi-layer paper bags.

 

Shelf Life

The shelf life of SuperEnro™ is two years from the date of manufacturing.

 

Bitterness Overcoming Mechanism

Cutting Technology Utilized in Producing SuperEnro™

Coating Bitterness-free Enrofloxacin 10% & 20% Premix

Picture 1: Technical Drawing of SuperEnro™ with Bitterness-free Technology (Coated Microgranules)

Base on the intensive study of the taste sense and the bitterness signaling pathway of swine, Insighter® employs its patented know-how to overcome bitterness of TAS2R receptor, enabling swine to take feed normally, without awareness of any presence of enrofloxacin.

The antimicrobial spectrum of enrofloxacin-ISTadd

 High bioavailability and safety enrofloxacin feed additives-ISTadd

Bioavailability of SuperEnro(enrofloxacin) feed additives-ISTadd

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